compounds of formulas i, ii, and iii; processes for the treatment or prevention of: improved health due to monoamine reuptake; at least one vasomotor symptom; at least one depressive disorder; at least one sexual dysfunction; for pain prevention; gastrointestinal or genitourinary disorder; of chronic fatigue syndrome; of fibromyalgia syndrome; of schizophrenia; and use of a compound

摘要

Compounds of formulas I, II and III; PROCESSES FOR THE TREATMENT OR PREVENTION OF: A HEALTH STATE BETTER DUE TO MONOAMINE RECAPTATION; AT LEAST ONE VASOMOTOR SYMPTOM; AT LEAST A DEPRESSIVE DISTURBANCE; At Least One Sexual Dysfunction; FOR THE PREVENTION OF PAIN; GASTROINTESTINAL OR GENITOURINARY DISORDER; OF CHRONIC FATIGUE SYNDROME; OF FIBROMYALGIA SYNDROME; SCHIZOPHRENIA; AND USE OF A COMPOUND. The present invention is directed to phenylaminopropanol derivatives of formulas I, II and III: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives and methods of using them for the prevention and treatment of reuptake-enhanced health conditions. including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders and combinations thereof, particularly the health conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urinary urge incontinence, fibromyalgia, pain, diabetic neuropathy, schizophrenia and combinations thereof.