EZH2 AND ANDROGEN RECEPTOR SIGNALING INHIBITORS AS TOOLS FOR TARGETING PROSTATE CANCER

摘要

Provided herein are methods of using (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide, or a pharmaceutically acceptable salt thereof and an androgen receptor signaling inhibitor for treating prostate cancer. Also provided are pharmaceutical compositions comprising (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1 H-indole-3-carboxamide, or a pharmaceutically acceptable salt thereof and an androgen receptor signaling inhibitor.