LEUKEMIA MARKER AND USE THEREOF IN ASSESSMENT OF LEUKEMIA PROGNOSIS

摘要

Disclosed is a leukemia marker. The leukemia marker is a gene set forth in SEQ ID No. 1 or a gene having 85% to 99% homology thereto. The marker is applicable to the preparation of a product for predicting or diagnosing whether a patient is one with refractory myeloid leukemia, or sorting a patient with refractory myeloid leukemia, and for predicting or diagnosing whether a patient is one with myeloid leukemia who has been treated to the degree of complete bone marrow remission but shows the risk of recurrence, or sorting a patient with myeloid leukemia who has been treated to the degree of complete bone marrow remission but shows the risk of recurrence, and for predicting or assessing the time remaining for a patient with myeloid leukemia. Detection of the marker prior to chemotherapy can help determine responsiveness to chemotherapy, recurrence, and the prognostic survival of a patient, and nicely distinguish chemotherapy-sensitive, refractory, and recurrent patients, so as to overcome the shortcomings of existing risk stratification and achieve the purpose of further fine stratification of patients, effectively providing guidance for subsequent chemotherapy and transplantation treatment programs.