HOLLOW FIBER TUBE AND METHOD FOR IN-VITRO LARGE-SCALE PRODUCTION OF RED BLOOD CELLS

摘要

Disclosed are a hollow fiber tube and method for in-vitro large-scale production of red blood cells. The diameter of the hollow fiber tube is 200-1,000 μm, a basal culture medium and/or gas can circulate in an inner cavity of the hollow fiber tube, and the tail end of the hollow fiber tube can be communicated with a basal culture medium container and/or an oxygen reservoir; the wall thickness of the hollow fiber tube is 20-80 μm, and components of the basal culture medium and/or gas is allowed to pass through one side of the inner cavity of the hollow fiber tube to the other side; and a group applicable to cell denucleation is at least provided on the outer surface of a tube wall of the hollow fiber tube. The method for in-vitro large-scale production of red blood cells facilitates denucleation and differentiation of erythroid progenitor cells.