ADHESIVE/ADSORPTION SWITCH ON NANOPARTICLES TO INCREASE TUMOR UPTAKE AND DELAY TUMOR CLEARANCE

摘要

Lipid-based nanocarriers (liposomes) loaded with a chemotherapeutic agent and exhibiting interstitial drug release and intratumoral adhesion are disclosed. The lipid- based nanocarriers disclosed herein include an 'adsorptive/adhesive switch' on the nanocarriers surface with the aim to increase the tumor residence times of the drug delivery nanocarriers and to slow down their tumor clearing kinetics. The switch is designed to promote nanoparticle adsorption on cancer cells and/or the extracellular matrix (ECM) while keeping their internalization by cells to a minimum. This approach of drug delivery is key for interstitial release of highly-diffusive forms of therapeutics.