首页>
外国专利>
METHODS FOR TREATING TRIPLE NEGATIVE BREAST CANCER USING A HUMAN ERBB-2 MUTANT PROTEIN
METHODS FOR TREATING TRIPLE NEGATIVE BREAST CANCER USING A HUMAN ERBB-2 MUTANT PROTEIN
展开▼
机译:使用人ERBB-2突变蛋白治疗三阴性乳腺癌的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
A method of treating Triple Negative Breast Cancer in a subject, which comprises delivering a nucleic acid sequence encoding a mutant Erb B-2 polypeptide in an amount effective to inhibit cancer cell proliferation, wherein the mutant Erb B-2 lacks a functional nuclear localization signal, cannot translocate to the nucleus of the cell in which it is present, and functions as a dominant-negative inhibitor of endogenous Erb B-2 by inhibiting nuclear translocation of endogenous Erb B-2 in the cell in which the mutant is present, wherein the mutant Erb B-2 polypeptide retains intrinsic tyrosine kinase activity and does not inhibit endogenous Erb B-2 tyrosine kinase activity.
展开▼