DERIVATIVES OF AZIRIDINE-2-CARBOXAMIDE AS INHIBITORS OF THIOREDOXIN REDUCTASE, THEIR SYNTHESIS, ANTI-CANCER AND ANTI-METASTATIC EFFECT

摘要

This invention relates to the novel potentially therapeutic compounds that contain l-acyl derivatives of aziridine-2-carboxamide and their analogues with the anticancer and/or antiproliferative, and/or antimetastatic properties and/or those with the thioredoxin reductase inhibitory activity as well as the application of these compounds in cancer treatment and/or prophylaxis and in the treatment of such diseases where thioredoxin reductase inhibition is crucial.