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IMMUNOLOGICAL COMPOSITION FOR DIAGNOSIS OF LUNG CANCER BY USING AUTOANTIBODY-ANTIGEN COMPLEX, DIAGNOSIS METHOD FOR LUNG CANCER BY USING SAME, AND LUNG CANCER DIAGNOSIS KIT COMPRISING SAME
IMMUNOLOGICAL COMPOSITION FOR DIAGNOSIS OF LUNG CANCER BY USING AUTOANTIBODY-ANTIGEN COMPLEX, DIAGNOSIS METHOD FOR LUNG CANCER BY USING SAME, AND LUNG CANCER DIAGNOSIS KIT COMPRISING SAME
The present invention relates to: an immunological composition for diagnosis of lung cancer, the immunological composition comprising antibody composition A containing anti-CYFRA21-1 primary antibody-gene and anti-CYFRA21-1 secondary antibody-detection label and antibody composition B containing anti-CYFRA21-1 primary antibody-gene and anti-human IgG antibody-detection label; a method for diagnosing lung cancer in a human biological sample by using same; and a lung cancer diagnosis kit using same. The composition and the method for diagnosis of lung cancer according to the present invention allow diagnosis of the onset of lung cancer in stages 0-4 with a specificity of 90% or higher and a sensitivity of 75% or higher in a non-invasive biological sample. Particularly, the composition and the method employ an autoantibody that sharply increases in concentration in the initial stage of lung cancer and as such, enable diagnosis of the onset of initial lung cancer in stages 0-1 with a sensitivity of 76% or higher.
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