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METHODS FOR THE MATURATION OF CARDIOMYOCYTES ON AMNIOTIC FLUID CELL-DERIVED ECM, CELLULAR CONSTRUCTS, AND USES FOR CARDIOTOXICITY AND PROARRHYTHMIC SCREENING OF DRUG COMPOUNDS
METHODS FOR THE MATURATION OF CARDIOMYOCYTES ON AMNIOTIC FLUID CELL-DERIVED ECM, CELLULAR CONSTRUCTS, AND USES FOR CARDIOTOXICITY AND PROARRHYTHMIC SCREENING OF DRUG COMPOUNDS
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机译:羊膜细胞衍生的ECM,细胞结构上的心肌细胞的成熟方法以及用于药物抗氧性和血友病性筛查的方法
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摘要
Disclosed herein are methods of using a cell-derived extracellular matrix derived in-vitro from cells isolated from amniotic fluid (AFC-ECM) for the maturation of immature cardiomyocytes derived from human induced pluripotent stem cells (immature hiPSC-CMs) in culture forming mature cardiomyocytes. Also disclosed herein is a cell construct comprising a monolayer of these mature cardiomyocytes on an AFC-ECM useful for cardiotoxicity and/or proarrhythmic screening assays of drug compounds. Also disclosed herein are methods for determining the cardiotoxicity and/or proarrhythmic effect of a drug compound in vitro using such cell constructs.
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