FULL HUMAN BROAD-SPECTRUM NEUTRALIZING ANTIBODY 4F1 AGAINST RESPIRATORY SYNCYTIAL VIRUS AND USE THEREOF

摘要

Disclosed are a full human broad-spectrum neutralizing antibody against respiratory syncytial virus and use thereof. Specifically, disclosed in the present invention are a full human monoclonal antibody 4F1 against a respiratory syncytial virus fusion protein (F protein) and pre-fusion F protein (preF protein), a nucleic acid sequence encoding said antibody and an antibody fragment, and a preparation method therefor. In vivo and in vitro experiments confirm that said 4F1 antibody can effectively prevent and control RSV infection, has low immunogenicity in the human body, can avoid immune rejection reactions mediated by heterogenetic antibodies such as human anti-mouse, and can be used clinically for preventing and treating respiratory syncytial virus infection.