PHARMACEUTICAL COMPOSITION, COMPRISING HUMAN HYALURONIDASE PH20 VARIANT AND DRUG, FOR SUBCUTANEOUS INJECTION

摘要

The present invention relates to a pharmaceutical composition comprising (a) a drug and (b) a human PH20 variant. The human PH20 variant contained in the pharmaceutical composition according to the present invention includes an amino acid substitution at one or more positions selected from the alpha helix 8 sequence (S347-C381) and a linkage region (A333-R346) between alpha helix 7 and alpha helix 8 on the wild-type human pH20 having the amino acid sequence of SEQ IS NO: 1, and is optionally cleaved at an amino acid positioned at the N-terminal or C-terminal region. In addition, the pharmaceutical composition according to the present invention may further comprise a pharmaceutically acceptable additive, particularly, a stabilizer. Due to the advantage of the human PH20 variant, the pharmaceutical composition according to the present invention can exhibit a maximum therapeutic effect of the drug used together therewith.