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SYNERGIST THERAPY FOR ENHANCED DRUG DELIVERY: MAGNETIC FIELD FACILITATED NANOPARTICLE MICROPORATION
SYNERGIST THERAPY FOR ENHANCED DRUG DELIVERY: MAGNETIC FIELD FACILITATED NANOPARTICLE MICROPORATION
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机译:增强药物输送的协同疗法:磁场促成的纳米微粒微污染
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摘要
Methods for enhancing intracellular uptake of active agents by inducing temporary pore formation in a cell membrane are described. The methods generally comprise introducing nanoparticles to a cell in vivo, ex vivo, or in cell culture to magnetic nanoparticles that are taken up into the cell interior. The methods further comprise introducing active agents to the cell. A magnetic field is applied to the cell for targeted excitation of the internalized magnetic nanoparticles to induce temporary pore formation in the cell membrane, such that the active agent is taken up in an increased amount and/or at an increased rate by the cell.
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