PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV) RESISTANT SWINE

摘要

Swine that are resistant to or not prone to infection by the porcine reproductive and respiratory syndrome virus (PRRSV) are provided. The animals are gene edited to alter the expression of CD163 which may comprise prevention of exon 7 of the gene which codes for amino acid residues in the SRCR5 trans membrane domain of CD163.