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COMPOSITION FOR DIAGNOSIS OR PROGNOSIS PREDICTION OF GLIOMA, AND METHOD FOR PROVIDING INFORMATION RELATED THERETO

机译:诊断胶质瘤或预测胶质瘤的组合物,以及提供胶质瘤相关信息的方法

摘要

The present invention relates to: a composition, a biomarker panel and a kit for the diagnosis or prognosis prediction of a glioma, all of which contain a drug for detecting a variation in a target gene; a method for providing information related to the diagnosis or prognosis prediction of a glioma; a biomarker panel for personalized medicine for a glioma; and a method for providing information for personalized treatment. According to one aspect, when a gene or protein variation is detected in one or more target genes selected from the group consisting of SAMD11, KLHL21, FAM167B, HPCAL4, GPBP1L1, LPHN2, GPR88, ZNF599, C19ORF33, B9D2, BCAM, CABP5, SIGLEC11, ERVV-2, ZNF865, MZF1, MRTO4, LRIG2, BSND, and SLC30A2, the diagnosis accuracy for a glioma diagnosis is high and the sensitivity is also high, and thus a glioma can be effectively diagnosed. Therefore, a drug for detecting a genetic variation in the target genes can be effectively used in a composition for the diagnosis or prognosis prediction of a glioma, a kit, a method for providing information, and a method for providing information for personalized treatment.
机译:本发明涉及用于神经胶质瘤的诊断或预后预测的组合物,生物标志物组和试剂盒,它们均包含用于检测靶基因的变异的药物。提供与神经胶质瘤的诊断或预后预测有关的信息的方法;用于神经胶质瘤的个性化药物的生物标志物面板;提供用于个性化治疗的信息的方法。根据一方面,当在一个或多个选自SAMD11,KLHL21,FAM167B,HPCAL4,GPBP1L1,LPHN2,GPR88,ZNF599,C19ORF33,B9D2,BCAM,CABP5,SIGLEC11的靶基因中检测到基因或蛋白质变异时,ERVV-2,ZNF865,MZF1,MRTO4,LRIG2,BSND和SLC30A2,对神经胶质瘤的诊断准确度高,敏感性也高,因此可以有效地诊断神经胶质瘤。因此,用于检测靶基因的遗传变异的药物可有效地用于神经胶质瘤的诊断或预后预测的组合物,试剂盒,提供信息的方法和提供信息的方法用于个性化治疗。

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