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METHOD OF TREATING AND PREVENTING BONE AND JOINT INFECTIONS
METHOD OF TREATING AND PREVENTING BONE AND JOINT INFECTIONS
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机译:治疗和预防骨和关节感染的方法
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摘要
The present disclosure is directed to a method of treating or preventing a bone or joint infection, which method comprises: administering a therapeutically effective amount of a PlySs2 lysin comprising the amino acid sequence of SEQ ID NO: 1 or a variant thereof having at least 80% identity to SEQ ID NO: 1, wherein the variant comprises bacteriocidal and/or bacteriostatic activity against the Gram-positive bacteria, to a subject in need thereof, optionally co-administered with one or more antibiotics, wherein the bone or joint infection comprises a Gram-positive bacteria, such as Staphylococcus epidermidis or Staphylococcus aureus. Methods for preventing or disrupting a Gram-positive bacterial biofilm formed in a synovial fluid, such as a biofilm formed by Staphylococcus epidermidis, are also disclosed.
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机译:本公开内容涉及一种治疗或预防骨或关节感染的方法,该方法包括:给予治疗有效量的包含氨基酸序列为SEQ ID NO:1的PlySs2溶素或其变体,所述变体具有至少80个与SEQ ID NO:1的同一性%,其中变体包含对革兰氏阳性细菌的杀菌活性和/或对有需要的受试者的抑菌活性,任选与一种或多种抗生素共同施用,其中骨或关节感染包括革兰氏阳性细菌,例如表皮葡萄球菌或金黄色葡萄球菌。还公开了用于预防或破坏在滑液中形成的革兰氏阳性细菌生物膜,例如由表皮葡萄球菌形成的生物膜的方法。
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