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A method for preparing a composition comprising a low dissolved oxygen content, acetaminophen and optionally one or more NSAIDs and the composition obtained thereby
A method for preparing a composition comprising a low dissolved oxygen content, acetaminophen and optionally one or more NSAIDs and the composition obtained thereby
The present invention provides a method for preparing an intravenously administrable aqueous composition comprising acetaminophen and optionally one or more nonsteroidal anti-inflammatory agents (NSAIDs), wherein the dissolved oxygen of the composition in the closed container is at most 1.0 ppm The method comprises washing at least once the blending vessel with water at a temperature of at least 80 ° C., thus heating the vessel and creating a low oxygen environment within the vessel; Dissolving acetaminophen in water for infusion in the cleaned vessel, wherein the water for infusion is at a temperature of at least 80 ° C. and optionally one or more NSAIDs are present prior to dissolution of acetaminophen or It is added later.
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