SH2 Src homology 2 domain Novel polypeptide selectively binding to SH2 domain of brutons tyrosine kinase and Uses thereof

摘要

The present invention relates to a novel polypeptide that selectively binds to the SH2 domain of bruton tyrosine kinase, and more particularly, to a polypeptide that binds to the SH2 domain of bruton tyrosine kinase, a polynucleotide encoding the polypeptide, and the polynucleotide. An expression vector comprising, a recombinant microorganism into which the expression vector is introduced, and a method for producing the polypeptide using the recombinant microorganism. In addition, a lipid body complex fused with the lipid body and the cell transfer peptide, a polynucleotide encoding the lipid body complex, an expression vector comprising the polynucleotide, a recombinant microorganism into which the expression vector is introduced and the recombinant microorganism It relates to a method for producing the lipid body complex using. Since the novel polypeptide according to the present invention can specifically bind to the SH2 domain of bruton tyrosine kinase and inhibit the activity of tumor-induced phosphorylase, it is possible to develop a preparation for the prevention or treatment of various cancers associated with bruton tyrosine kinase. It can be widely used.