Construction of A Non-Redundant Human SH2 Domain Database

摘要

Domain database is essential for domain property research. Eliminating redundant information in database query is very important for database quality. Here we re- port the manual construction of a non-redundant human SH2 domain database. There are 119 human SH2 domains in 110 SH2-containing proteins. Human SH2s were aligned with ClustalX, and a homologous tree was generated. In this tree, proteins with similar known function were classi?ed into the same group. Some proteins in the same group have been reported to have similar binding motifs ex- perimentally. The tree might provide clues about possible functions of hypothetical proteins for further experimental veri?cation.