arm-PCR IDENTIFICATION OF ANTIGEN-SPECIFIC ADAPTIVE IMMUNE RESPONSES USING ARM-PCR AND HIGH-THROUGHPUT SEQUENCING

摘要

The present invention discloses a method of associating one or more amino acid sequences from an antibody isolated from human or animal blood with one or more DNA sequences corresponding to the antibody in a human or animal immune repertoire. The method also provides means for pairing heavy and light chains to produce synthesized monoclonal antibodies.