Assays to Measure the Efficacy of Receptor-ligand Interactions in Nanomedicine

摘要

Described herein are isolated cells comprising a recombinant T cell receptor (TCR) specific for a disease associated antigen bound to an MHC molecule and a TCR pathway dependent reporter. Use the isolated cells as assays to measure the function or efficacy of a peptide-major histocompatibility complex (pMHC) (pMHC-NP) coupled to nanoparticles that can be used as a medicament for treating autoimmune disease or cancer. Also described is a method.