EPB41L5 A Epitope of EPB41L5 and monoclonal antibody

摘要

The present invention has discovered, following an investigation into the effects of TGFβ/Smad3/EPB41L5 molecular mechanisms in cancer cells, that a high level of expression of EPB41L5 is related to the overall survival rate of cancer patients, and has confirmed that EPB41L5 is a potential prognostic indicator of cancer. The present invention thus specifies an epitope of EPB41L5, which allows recognition of EPB41L5 as an antigen, and relates to an antibody, or a fragment thereof, which specifically binds to the epitope of EPB41L5. The antibody according to the present invention can be usefully employed as a therapeutic agent for EPB41L5-related cancer.