The manufacturing and refining method of miniaturized prosper

摘要

A compound of general formula I (where R is a straight or branched c1-4alkyl group),Among them, as an expert in the manufacture of Metso,The vinyl alkane of general formula III is reacted with copper halide CuX and alkyllithium r1li to make the plastic copper acid couple ring of general formula II (R2 in the formula is an alcohol protector containing H or silicon atoms,For example, trimethyl silica gel -,Triethyl silica gel -,Tert-dimethylsilyl,Or the ring or open chain of oxygen atoms,For example, terahead -,Display the metal flag of metal - or talk;X represents phase I, Br, CN, SCN and oso2cf,R1 is C1-6 alkyl,When R2 is not a hydrogen atom, n 2, R2 is a hydrogen atom, n 3General formula IV (R3 in the formula is THP - or Trier base,The meaning of R is the same as that defined above) the protected rice field participates in the reaction of cuprate,Compared with a) copper iodide (I), the reaction of cuprate with R ≠ h is 2 to 2.4G,R2 = h is a ratio of 3 to 3.4,The excess lithium alkyl is broken down before the couple rings of II and IV react,b) The compound protector of the general chemical formula V (R, R2 and R3 in the chemical formula can relieve the above provisions),The obtained compound of general formula I is refined by chromatography,Compounds of general formula I,Among them, the manufacture by the experts of Mercure.