ERK_MAPK ERK_MAPK ERK_MAPK Bio-Marker Composition for Sensitivity Prediction of ERK_MAPK Drug Estimation Method for Sensitivity Prediction of ERK_MAPK Drug using Bio-Marker Composition and Diagnosing Chip for Detection of Bio-Marker Composition for Sensitivity Prediction of ERK_MAPK Drug

摘要

The present invention relates to a biomarker composition for evaluating ERK_MAPK drug responsiveness using cancer biomarker labeling scan (GBLscan), which is a new learning model capable of predicting haplotype biomarker containing ERK_MAPK drug responsiveness functional information, thereby enabling a reliable prediction and drug labeling of ERK_MAPK drug responsiveness. In particular, the present invention relates to a biomarker composition consisting a combination of markers containing mutations regulating gene expressions for evaluation responsiveness with respect to ERK_MAPK drugs, wherein the biomarker composition comprises 2_72891611_A_C (Marker 1) and 1_8013331_A_G (Marker 2). According to the present invention, the biomarker composition enables the prediction of sensitivity to ERK_MAPK drugs by subject′s genotype by means of biomarkers to ERK_MAPK-related drugs, and thus can enable an effective preliminary testing not only in the field of personalized medicine, but also in screening of new drug candidates.