METHODS FOR PREPARING IN VITRO CULTURED HEPATOCYTES USING ER STRESS RELIEVER AND IN VITRO CULTURED HEPATOCYTES PREPARED BY THEREOF

摘要

The present invention relates to a method for manufacturing in vitro cultured hepatocytes using an endoplasmic reticulum stress reliever, and in vitro cultured hepatocytes manufactured through the method. Particularly, the present invention relates to a technology for differentiating pluripotent stem cells into hepatocytes, culturing hepatoma cell lines, or culturing primary cultured hepatocytes, using an endoplasmic reticulum stress reliever, to prepare in vitro cultured hepatocytes which have improved functionality and which can be used in a test for prediction of the hepatotoxicity of novel drug candidates.