Methods for treating netosis and neutrophil activation

摘要

Methods and compositions are described herein for methods of inhibiting neutrophils, eg, NET release or netosis, by DEspR inhibitors, eg, anti-DEspR antibody reagents. In some embodiments, the method comprises a disease, eg, cancer or neutrophils; NET; Or netsing or netting neutrophils may be involved in the treatment of diseases that contribute to the pathogenesis, chronicity, or exacerbation of the disease. In some embodiments, the DEspR inhibitor can be a bispecific reagent or antibody-drug conjugate.