Method for evaluating the risk of drug adverse reactions of the skin caused by the anti-epileptic drug lamotrigine, detection reagents therefor and use thereof

摘要

A method for evaluating the risk of drug adverse reactions of the skin caused by the anti-epileptic drug lamotrigine, wherein the drug adverse reactions of the skin include: hepatic rash (MPE), fixed drug rash (FDE), Stevens Johnson syndrome (SJS), The method is provided, including but not limited to, toxic epidermal necrosis (TEN), eosinophilia and drug rash (DRESS) with systemic symptoms. Also provided are detection reagents and uses thereof for evaluating the risk of a patient having a drug adverse reaction of the skin caused by an anti-epileptic drug lamotrigine comprising a substance that measures a specific HLA allele.