Deuterium-enriched N-acetylcysteine amide (D-NACA) and (2R,2R')-3,3'-disulfanediyl bis(2-acetamidopropanamide) (Di-NACA) production method and oxidative stress Method of using D-NACA and Di-NACA to treat diseases including

摘要

The present invention provides (2R,2R'')-3,3''-disulfanediyl bis(2-acetamidopropanamide) (Di-NACA) or D ₃ -N with deuterium enrichment in excess of the natural abundance of deuterium. -Acetyl cysteine amide or a physiologically acceptable salt thereof, a pharmaceutical composition comprising a derivative or solid thereof, and using Di-NACA for eye diseases, and for example, anti-serpent toxin, beta-thalassemia, cataract , Chronic obstructive pulmonary disease, macular degeneration, contrast-induced kidney disease, asthma, lung injury, metaamphetamine-induced oxidative stress, multiple sclerosis, Parkinson''s disease, platelet apoptosis, delayed dyskinesia, Alzheimer''s disease, HIV-1 related dementia, mitochondria Diseases, cardiomyopathy, neurodegenerative diseases, pulmonary fibrosis, skin pigmentation, skin requiring regeneration, antibacterial infections, and methods for treating oxidative damage related diseases including Friedreich''s ataxia.