Animal model of schizophrenia and manufacturing method thereof

摘要

The present invention relates to an animal model of schizophrenia, a method for manufacturing the same, and the like, characterized in that the mouse is a specific ANO1 (Anoctamin 1) gene-deficient mouse in cholinergic neurons of the medial reins nucleus. The animal model of schizophrenia according to the present invention targets the medial halter nucleus, which is a brain tissue that functions primarily in the pathogenesis of schizophrenia, and is positive for schizophrenia when the ANO1 gene is specifically deleted in cholinergic neurons of the medial halter nucleus. Since the symptoms, negative symptoms, and cognitive symptoms were confirmed to confirm that schizophrenia was induced, the animal model of the present invention is expected to be usefully used as an animal model for research on the pathogenesis of schizophrenia, development of therapeutic agents, and screening. .