The present invention is a method for manufacturing porous silica nanospheres that can control the size and number of pores and the thickness of the shells in the shell of the porous silica nanospheres having hollow pores on the inside and having pores on the surface, and the interior hollow space of the porous silica nanospheres. A method for preparing hollow porous silica nanospheres that can be utilized as a drug carrier by loading a drug and allowing the drug to be slowly released, and synthesizing a template polymer having a functional group on the surface. ; Synthesizing porous silica nanospheres by depositing a silica precursor in a basic solution on the surface of the template polymer; And synthesizing the hollow porous silica nanospheres by firing and removing the template polymer, thereby providing a hollow porous silica nanosphere manufacturing method and a hollow porous silica nanosphere.
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