Ag85A Vaccine composition for preventing tuberculosis containing a glycosylated Ag85A protein and method for producing the vaccine composition

摘要

The present invention relates to a vaccine composition for preventing tuberculosis comprising a glycosylated Ag85A protein, a vector for preparing the protein, a transformant using the vector, and a method for producing a glycosylated Ag85A protein using the transformant, etc. As it is, the vaccine composition comprising the glycated Ag85A protein of the present invention has the effect of inducing the multifunctional T cell secretion of IFN-γ, TNF-α and IL-2, which are important for the tuberculosis defense effect, and thereby prevents tuberculosis It can be usefully used as a vaccine, and further, the glycosylated Ag85A protein can be effectively expressed in plants and separated in high yield using a vector optimized for protein production, thereby enabling mass production at low cost.