Anti-BMP10 antibody and therapeutic agent for hypertension and hypertensive diseases using the antibody as an active ingredient

摘要

An object of the present invention is to provide an anti-BMP10 antibody and a therapeutic agent for hypertension and hypertensive diseases using the antibody as an active ingredient. The present invention relates to an anti-BMP10 monoclonal antibody or antibody fragment thereof that binds to human BMP10 (Bone morphogenetic protein-10). In addition, the present invention is a therapeutic agent for hypertension and hypertensive diseases, including an antagonist for at least one of BMP10 and BMP9/BMP10 heterodimer, a diagnostic drug or pharmaceutical composition for diseases involving human BMP10, and human BMP10 using the antagonist It relates to an immunological detection method or measurement method of, and the use of the antagonist for the manufacture of a pharmaceutical composition for the treatment of hypertension and hypertensive diseases.