PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACT OF PINE POLLEN AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME

摘要

The present invention relates to a pharmaceutical composition and health functional food for the prevention or treatment of thrombosis containing a pine tree extract as an active ingredient, and more specifically, an ethyl acetate fraction of an ethanol extract of pine tree flour, It relates to a pharmaceutical composition for preventing or treating/improving thrombosis by inhibiting blood coagulation and inhibiting platelet aggregation containing a butanol fraction, a water residue after an organic solvent fraction, or a mixture thereof as an active ingredient, and a health functional food. Songhwamin extract as an active ingredient of a pharmaceutical composition for preventing or treating thrombosis and a health functional food of the present invention is due to the inhibitory effect of platelet aggregation, which plays a role in initiating thrombus formation along with inhibition of blood clotting-related enzymes and blood clotting factors. At the same time, it exhibits strong antithrombotic activity, does not show any hemolytic activity against human red blood cells, has excellent thermal stability, and shows a loss of blood coagulation factor inhibitory effect and blood clot formation-related enzyme inhibitory effect even in acidic conditions of pH 2 and plasma. Therefore, it is expected that it can be used for the prevention and treatment of thrombosis such as ischemic stroke and hemorrhagic stroke through improvement of blood circulation, and the active ingredient is processed into various forms such as extract, powder, pills, tablets, etc. It is a very useful invention in the pharmaceutical industry and food industry because it has an excellent effect that can be prepared with.