MASP-1 MASP-2 / MASP-3 COMPOSITIONS AND METHODS OF INHIBITING MASP-1 MASP-2 AND/OR MASP-3 FOR TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA

摘要

MASP-3-dependent complement activation in individuals suffering from paroxysmal nocturnal hemoglobinuria by administering a composition containing an amount of a MASP-3 inhibitor in an amount effective to inhibit MASP-3-dependent complement activation to an individual. Methods and compositions for inhibition are provided. In addition, increasing the survival rate of red blood cells in an individual suffering from paroxysmal nocturnal hemoglobinuria by administering a composition comprising an amount of at least one of a MASP-1 inhibitor and/or a MASP-3 inhibitor effective to increase the survival rate of red blood cells. Methods and compositions for this are provided. Subject to be administered a MASP-2 inhibitory agent and a MASP-1 inhibitor, a MASP-2 inhibitory agent and a MASP-3 inhibitor, a MASP-3 inhibitor and a MASP-1 inhibitor, or a MASP-1 inhibitor, a MASP-2 inhibitor, and a MASP-3 inhibitor. May be.