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Novel radiometal-binding compounds for diagnosis or treatment of prostate specific membrane antigen-expressing cancer
Novel radiometal-binding compounds for diagnosis or treatment of prostate specific membrane antigen-expressing cancer
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机译：用于诊断或治疗表达前列腺特异性膜抗原的癌症的新型放射性金属结合化合物
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摘要
The present application relates to a compound of formula (Ia) or formula (lb), or is a salt or solvate thereof. R 1 is -(CH 2 ) 5 CH 3 or contains 2-4 fused benzene rings. R 2 is I, Br, F, Cl, H, OH, OCH 3 , NH 2 , NO 2 or CH 3 . R 3 is a peptide-linked glycine, aspartate or glutamate, or a glutamate peptide linked through C delta . L is -CH 2 NH-, -(CH 2 ) 2 NH-, -(CH 2 ) 3 NH-, or -(CH 2 ) 4 NH-. R 4 is a radiometal chelator optionally linked by radiometal. The variable'n' is 1-3. The compounds may be useful for imaging prostate specific membrane antigen (PSMA)-expressing tissue or for treating PSMA-expressing diseases (eg, cancer).
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