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New alkyldiphenylmethane protective agent

机译:新型烷基二苯基甲烷保护剂

摘要

Provides an alkyldiphenylmethane protecting agent that facilitates separation and purification after the reaction without solidifying or insolubilizing the compound protecting the functional group. General Formula (1) (In the formula, Y is -OR 19 (wherein R 19 represents a hydrogen atom or an active ester type protecting group), -NHR 20 (where R 20 is a hydrogen atom, a straight chain having 1 to 6 carbon atoms or Represents a branched alkyl group or aralkyl group), an isocyanate group, an azide group, or a halogen atom, Z represents a C 1 to C 4 linear or branched alkyl group or alkenyl group, or a cycloalkyl group, R 1 to At least one of R 10 represents a group represented by formula (2), and the rest represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; R 11 is a straight chain having 1 to 16 carbon atoms Or a branched chain alkylene group; X represents O or CONR 21 (here, R 21 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms); A represents formula (3) and the like (here R 12 , R 13 and R 14 are the same or different, and represent a C 1 to C 6 linear or branched alkyl group or an aryl group which may have a substituent; R 15 is a single bond or a C 1 to C 3 linear or branched alkylene A group, and R 16 , R 17, and R 18 each represent a linear or branched alkylene group having 1 to 3 carbon atoms).
机译:提供一种烷基二苯基甲烷保护剂,其在反应后促进分离和纯化,而不会固化或不溶解保护官能团的化合物。通式(1)(式中,Y为-OR 19 (其中R 19 表示氢原子或活性酯型保护基),-NHR 20 (其中R 20 是氢原子,具有1-6个碳原子的直链或表示支链烷基或芳烷基),异氰酸酯基,叠氮基, Z代表卤代碳原子或卤素原子,Z表示碳原子数为1至C 4的直链或支链烷基或烯基,或环烷基,R 1 至R 10 中的至少一个代表由式(2)表示的基团,其余代表氢原子,卤素原子,具有1-4个碳原子的烷基或具有1-4个碳原子的烷氧基; R 11 是具有1至16个碳原子的直链或支链亚烷基; X表示O或CONR 21 (此处R 21 表示氢原子或烷基具有1-4个碳原子的基团); A代表式(3)等(此处R 1 2 ,R 13 和R 14 相同或不同,表示C 1至C 6的直链或支链烷基或芳基,有取代基R 15 是单键或C 1至C 3线性或支链亚烷基A基团,R 16 ,R 17,和R 18 分别表示具有1-3个碳原子的直链或支链亚烷基。

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