Injectable compositions of triterpenoid antifungal agents encapsulated in liposomes

摘要

Injectable compositions of single bilayer vesicles encapsulating an enfumafungin derived triterpenoid antifungal compound can be administered intravenously to treat or prevent fungal infections while reducing local injection site reactions (ISR). Enfumafungin derived triterpenoid antifungal compounds are inhibitors of (1,3)-β-D-glucan synthesis, and fungal infections such as systemic fungal infections, including those caused by Candida and Aspergillus species It is useful for the treatment or prevention of