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Composition in the form of an aqueous solution for injection comprising amylin, amylin agonist receptor or amylin analog and co-polyamino acid

机译:注射水溶液形式的组合物,其包含胰岛淀粉样多肽,胰岛淀粉样多肽激动剂受体或胰岛淀粉样多肽类似物和共聚氨基酸

摘要

The present invention comprises a pH of 6.0 to 8.0, at least a) amylin, amylin receptor agonist or amylin analog; b) a co-polyamino acid having a carboxylate charge and a hydrophobic radical Hy, wherein the co-polyamino acid is composed of glutamic acid or aspartic acid units, and the hydrophobic radical -Hy is selected from radicals according to Formula X. -It relates to a composition in the form of an aqueous solution for injection, containing a polyamino acid, characterized in that the composition does not contain a basal insulin containing an isoelectric point pI of 5.8 to 8.5. The present invention further relates to a composition comprising postprandial insulin.
机译:本发明包含6.0至8.0的pH,至少a)胰岛淀粉样多肽,胰岛淀粉样多肽受体激动剂或胰岛淀粉样多肽类似物; b)具有羧酸盐电荷和疏水基Hy的共聚氨基酸,其中该共聚氨基酸由谷氨酸或天冬氨酸单元组成,并且疏水基-Hy选自式X的基团。本发明涉及包含聚氨基酸的注射水溶液形式的组合物,其特征在于,所述组合物不包含基础胰岛素,所述基础胰岛素的等电点pI为5.8至8.5。本发明进一步涉及包含餐后胰岛素的组合物。

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