An animal model of congenital lymphatic malformation and use thereof

摘要

The present invention relates to a congenital lymphatic vessel development abnormal animal model and use thereof. Specifically, in the embryos of the Tmem100 knockout mouse of the present invention, the differentiation of lymphatic endothelial cells is increased, and according to the abnormal connection between the main vein and the lymphatic vessels, phenotypes such as blood-filled lymphatic vessels, expanded lymphatic vessels, and lymphocytes appear, and Tmem100 overexpressing mice the embryo is opposed to reducing the differentiation of lymphatic endothelial cells and lymphatic vessels, and new reduction, severe subcutaneous edema and lymphatic vessels, bar phenotype appearing, such as reducing the size and number of lymphoid follicles, Tmem100 knockout mice and Tmem100 overexpressing mice with congenital lymphatic It can be used as an animal model useful for basic research on developmental abnormalities and development of preventive or therapeutic agents.