miR-142-3p Recombinant vector containing target sequence for miR-142-3p

摘要

The present invention relates to a recombinant vector comprising a target sequence of miR-142-3p and various uses thereof. The recombinant vector of the present invention inserts a sequence targeting miR-142-3p at the end of the AIMP2 variant to control the side effects that the AIMP2 variant overexpresses in tumors, and is expressed in CD45-derived cells, in particular, lymphocyte and leukocyte lineage cells. It has the effect of controlling so that it is suppressed. Therefore, since the AIMP2 variant can be specifically expressed only in neurons and can be selectively expressed only in brain tissues among various tissues, it can be usefully used in related industries.