Medications for the prevention or treatment of ophthalmic diseases accompanying intraocular angiogenesis and/or hyperintraocular vascular permeability

摘要

It provides a medicament for the prevention or treatment of an ophthalmic disease accompanying intraocular angiogenesis and/or hyperintraocular vascular permeability. The inventors of the present invention investigated a medicament for the prevention or treatment of ophthalmic diseases accompanying intraocular angiogenesis and/or hyperintraocular vascular permeability, and a selective S1P receptor agonist having an agonist activity for the S1P ₁ receptor is intraocular angiogenesis. The present invention was completed by confirming that it has an inhibitory effect and an inhibitory effect on intraocular vascular permeability. The compound or a pharmaceutically acceptable salt thereof, which is a selective S1P receptor agonist having an agonist activity against the S1P ₁ receptor of the present invention, has an inhibitory effect on intraocular angiogenesis and intraocular vascular permeability, and exudative aging macular degeneration, diabetic retinopathy, It can be used as a preventive and/or therapeutic agent for diabetic macular edema, myopic choroidal neovascularization, retinal artery occlusion, retinal vein occlusion, or angiogenic glaucoma.