MULTI-ORGAN-CHIP WITH IMPROVED LIFE TIME AND HOMOEOSTASIS

摘要

The present invention relates to a manifold chip device, the manifold chip device comprising: a base layer; An organ layer arranged on said base layer; A cavity layer arranged on said organ layer; And an actuator layer; Wherein the base layer is configured to provide a rigid support for another layer; The organ layer comprises a plurality of individual organ equivalents, ie each organ equivalent comprising one or more organ growth sections, an organ tube cavity for housing at least one organ tube of the organ and the organ tube cavity of the organ growth section And each organ growth section configured to include a small inlet and a small outlet for fluid communication between the circulatory system and a separate circulation system, wherein the organ layer comprises organs of the lung, small intestine, spleen, pancreas, liver, kidney and bone marrow. Comprise at least one organ equivalent, each configured to represent, and an independent circulation system configured to be in direct fluid communication with the organ growth section of the organ layer through the small inlet and outlet of the organ growth section; The cavity layer is configured to have a plurality of cavities and tubes arranged in fluid communication with a selected organ equivalent or organ growth section to allow fluid exchange between the cavity and the organ growth section; And the actuator layer is configured to include a plurality of actuators arranged and configured to adjust the pressure that may be applied to a selected organ equivalent, an independent circulation system, and / or a portion thereof.