BIOMARKER COMPOSITION FOR PREDICTION OF THE COMPOUNDS CAUSING HEPATOTOXICITY AND SCREENING METHOD OF THE COMPOUNDS CAUSING HEPATOTOXICITY USING THE SAME

摘要

The present invention relates to a biomarker composition for predicting hepatotoxicity-causing substances and a screening method of hepatotoxicity-causing substances using the same, and more particularly, to which compounds are toxic in human liver cells. A method for effectively screening a compound that induces hepatotoxicity by measuring and comparing the expression level of the biomarker gene in human hepatocytes treated with any compound using the biomarker composition as a marker capable of effectively predicting whether or not the biomarker composition It is about. According to the biomarker composition for predicting hepatotoxicity of the present invention and the screening method of the hepatotoxicity-inducing substance using the biomarker composition, the expression level of the novel biomarker gene of the present invention in hepatocytes derived from human embryonic stem cells in vitro. By measuring and comparing the results, it is possible to quickly and accurately determine whether hepatic toxicity may be caused by a candidate drug, and thus it is highly applicable to the field of molecular diagnostics and is a very useful invention for the medical industry.