首页> 外国专利> N-5S6S9R-5--6-23--6789--5H-b-9--4-2--23--1H-45-b-1--1- N-5S6S9R-5-AMINO-6-23-DIFLUOROPHENYL-6789-TETRAHYDRO-5H-CYCLOHEPTABPYRIDIN-9-YL-4-2-OXO-23-DIHYDRO-1H-IMIDAZO45-BPYRIDIN-1-YLPIPERIDINE-1-CARBOXYLATE HEMISULFATE SALT

N-5S6S9R-5--6-23--6789--5H-b-9--4-2--23--1H-45-b-1--1- N-5S6S9R-5-AMINO-6-23-DIFLUOROPHENYL-6789-TETRAHYDRO-5H-CYCLOHEPTABPYRIDIN-9-YL-4-2-OXO-23-DIHYDRO-1H-IMIDAZO45-BPYRIDIN-1-YLPIPERIDINE-1-CARBOXYLATE HEMISULFATE SALT

机译:N-5S6S9R-5--6-23--6789--5H- [b] -9--4-2--23--1H- [45-b] -1--1- N-5S6S9R-5 -AMINO-6-23-二氟苯基-6789-四氢-5H-环庚烷[B] PYRIDIN-9-YL-4-2-OXO-23-DIHYDRO-1H-咪唑[45-B] PYRIDIN-1-YLPIPERIDINE-1 -羧酸盐半硫酸盐

摘要

Hemisulfate salts of compound (I) and crystalline forms of hemisulfate salts are disclosed. Also disclosed are methods of using the hemisulphate salt of compound (I) as CGRP receptor antagonist and pharmaceutical compositions comprising the hemisulfate salt of compound (I). Hemisulphate salts of Compound (I) are used to treat migraines and other headaches, neurovascular expansion, neurological inflammation, heat damage, cyclic shock, redness associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive pulmonary disease (COPD). Useful for treating, preventing or ameliorating disorders, including.
机译:公开了化合物(I)的半硫酸盐和半硫酸盐的结晶形式。还公开了使用化合物(I)的半硫酸盐作为CGRP受体拮抗剂的方法和包含化合物(I)的半硫酸盐的药物组合物。化合物(I)的半硫酸盐用于治疗偏头痛和其他头痛,神经血管扩张,神经炎症,热损伤,周期性休克,与更年期相关的充血,气道炎性疾病(如哮喘)和慢性阻塞性肺病(COPD)。可用于治疗,预防或改善疾病,包括。

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