PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF BLOOD BRAIN BARRIER DISORDER COMPRISING L-SERINE AS AN EFFECTIVE COMPONENT AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME

摘要

The present invention relates to a composition for preventing, improving or treating neurodevelopmental disorders comprising the amino acid L-serine as an active ingredient, specifically securing a technology capable of diagnosing L-serine biosynthetic disorders in patients with neurodevelopmental disorders And it was confirmed the effect of improving clinical symptoms by supplying L-serine. In addition, since it was confirmed to restore the destroyed blood-brain barrier, it is expected to be applicable to the prevention and treatment of hypoxic ischemic brain injury, traumatic brain injury, neuroinflammatory disease, cerebrovascular disease, degenerative neurological disease, concentration disorder, memory disorder, etc. do. However, L-serine has a low brain absorption rate, so it is necessary to develop a composition capable of maximizing the therapeutic effect only by diet. Through the diagnostic methods and compositions established through the present invention, it can be usefully used to present guidelines for effective prevention and treatment of various neurological diseases.