-3- Composition for photodynamic diagnosis or therapy comprising indole-3-acetic acid

摘要

The present invention relates to a composition for photodynamic diagnosis or treatment comprising indole-3-acetic acid, a pH-sensitive block copolymer (poly (aspartic acid-grafting) in which imidazole is grafted to poly (aspartic acid) -polyethylene glycol. -Imidazole) -polyethylene glycol) was prepared, and indole-3-acetic acid was encapsulated in the block copolymer to prepare a drug carrier composition having a micelle structure. The composition forms a micelle structure at a pH of 7.4 or higher in response to a change in the body's pH, and in a cancer cell environment exhibiting weak acidity (pH 6.5 to pH 7.2), the micelle structure collapses to control target drug delivery and drug release to cancer cells, thereby treating cancer The effect can be improved. In addition, the indole-3-acetic acid encapsulated in the composition can be used for photodynamic therapy by generating more free radicals under visible light to selectively cause cytotoxicity to cancer cells and induce apoptosis. Therefore, the composition comprising indole-3-acetic acid having the above-described effect can be utilized in a pharmaceutical composition for photodynamic therapy, a pharmaceutical composition for photodynamic treatment of cancer disease, or a pharmaceutical composition for photodynamic diagnosis, in addition to cancer cells. It can be used to develop medicines for the diagnosis and treatment of lesions with weakly acidic pH.