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DNA MUTATIONAL ANALYSIS OF PLASMA DNA FOR CANCER DETECTION
DNA MUTATIONAL ANALYSIS OF PLASMA DNA FOR CANCER DETECTION
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机译:用于癌症检测的血浆DNA的DNA突变分析
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摘要
The frequency of somatic mutations in a biological sample (eg plasma or serum) of a subject screening or monitoring cancer can be compared to that in the constitutive DNA of the same subject. Parameters can originate from these frequencies and can be used to determine the classification of the level of cancer. False positives are filtered by requiring any variant locus to have at least a defined number of variant sequence reads (tags), requiring any variant locus to have at least a defined number of filtered, providing more precise parameters to eliminate filtering I can do it. The relative frequency for different variant loci can be analyzed to determine the level of heterogeneity of the tumor in the patient.
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