Chemical reprogramming of human glial cells into neurons using small molecule mixtures

摘要

Provided are compositions, products and methods related to promoting neuroforming or neuronal regeneration in a mammalian nervous system. Embodiments relate to the use of a group of compounds comprising crizotinib (Cri), flubiprofen, lithium chloride (Li), vitamin C (VC), ceritinib (Cer) or pirfenidone (PFD). will be. In certain embodiments, glia are converted to functional neurons.