Nano particle comprising self-assembled ferritin structure conjugated with antigen peptide and adjuvant and use thereof

摘要

The present invention relates to ferritin nanoparticles to which an antigenic peptide and an immune enhancer are coupled, by indirectly binding an antigenic peptide or an immune enhancer to a ferritin self-assembly using HTT ^cys peptide and V _L 12.3 ^cys peptide, antigen and immune enhancer It is possible to produce a fusion protein more easily than when directly fused, and also, it is possible to easily control the relative molar ratio of the antigen and the immune enhancer through this, and thus can be usefully used as a vaccine composition.