mSIN1 Pharmaceutical composition for preventing or treating infertility or abortion comprising inhibitors of mSIN1 protein as an active ingredient

摘要

The present invention relates to a pharmaceutical composition for preventing or treating infertility or miscarriage containing DEPTOR (DEP domain-containing mTOR-interacting protein) protein inhibitor or mSIN1 (mammalian stress-activated protein kinase interacting protein 1) protein inhibitor as an active ingredient. will be. Specifically, in the present invention, the activity of mTORC1 (mammalian target of rapamycin complex 1) increases during the decidualization process, the activity of mTORC2 decreases, and the negative regulator of mTORC1, the DEPTOR protein DEPTOR protein inhibitors or mSIN1 protein inhibitors are useful for the treatment of infertility or miscarriage by confirming that expression and binding to mTORC1 decrease, and expression of mSIN1 protein, a positive regulator of mTORC2, and binding to mTORC2 decreases. Can be used.