Vaccine composition for oral administration comprising an inactivated microbial cell encapsulated by a hydrogel

摘要

The present invention relates to a vaccine composition for oral administration containing an inactivated microbial cell encapsulated by a hydrogel. The present invention provides the oral vaccine composition for carnivorous fish which encapsulates a pathogen using the hydrogel which reversibly expands or contracts and changes in size according to a change in pH, so that the vaccine composition is not digested in a stomach with a low pH and is decomposed after being delivered to a high pH intestine, thereby being effectively absorbed to the body. In addition, the vaccine composition is possible to minimize stress-producing factors of living organisms since the vaccine composition can be administered in combination with food, can improve an antibody titer, and can inhibit the occurrence of side effects such as melaninization and autoimmunity due to the absence of adjuvant use.